The very low boiling point of inert gases is a widely used cryogenic working medium, especially liquid helium with boiling point as low as 4.2K (-268.95°C).

Superconducting magnets that can be used to cool NMR imaging and NMR spectroscopy, although liquid neon is not as cool as liquid helium, are still widely used in cryology because it cools 40 times as much as liquid helium and three times as much as liquid hydrogen.

Because helium is less soluble in liquids, especially lipids, it replaces nitrogen in the diver's breathing, and when you're under pressure like scuba diving, the gas is absorbed by the blood and the tissues of the body, which can have serious consequences of nitrogen anesthesia.

Because solubility is far less than nitrogen, a small amount of helium is carried into the cell membrane, and helium is used instead of some of the components in the respiratory mixture (such as a mixture of tri-mix and helium-oxygen).

The low solubility of helium provides a good solution to decompression sickness. The bubbles formed by decompression are greatly reduced when floating.

Argon, another inert gas, is considered the best waterproof gas for scuba diving, and helium is also used as a filler for nuclear fuel rods in nuclear reactors.